Toggle Main Menu Toggle Search

Open Access padlockePrints

Tregs and rheumatoid arthritis

Lookup NU author(s): Dr Amy AndersonORCiD, Professor John IsaacsORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.

Publication metadata

Author(s): Anderson AE, Isaacs JD

Publication type: Article

Publication status: Published

Journal: Acta Reumatológica Portuguesa

Year: 2008

Volume: 33

Issue: 1

Pages: 17-33

Print publication date: 01/03/2008

ISSN (print): 0303-464X

Publisher: Sociedade Portuguesa de Reumatologia


Notes: Journal Article Portugal