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Lookup NU author(s): Dr Amy AndersonORCiD,
Professor John IsaacsORCiD
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Regulatory T cells (Tregs) are a subset of T cells which are involved in peripheral immune tolerance. Their role in autoimmune disease which occurs through a breakdown of tolerance is of particular interest in trying to ascertain the mechanism(s) of disease progression. It is hoped that by understanding the role of Tregs in autoimmunity a reliable therapy may be developed to aid in both the treatment and potentially cure of disease. This review will focus on the naturally-occurring CD4+ CD25+ regulatory T cell subset and their possible involvement in rheumatoid arthritis.
Author(s): Anderson AE, Isaacs JD
Publication type: Article
Publication status: Published
Journal: Acta Reumatológica Portuguesa
Print publication date: 01/03/2008
ISSN (print): 0303-464X
Publisher: Sociedade Portuguesa de Reumatologia
Notes: Journal Article