Toggle Main Menu Toggle Search

Open Access padlockePrints

Geographical and ecological analyses of childhood acute leukaemias and lymphomas in north-west England

Lookup NU author(s): Dr Richard McNallyORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Childhood leukaemias and lymphomas have been associated with exposure to environmental factors, including infections, which show geographical variation. This study examined the geographical distribution of the incidence of acute leukaemia and lymphoma using Manchester Children's Tumour Registry (MCTR) data 1976–2000. A total of 910 children were included, all of whom had histologically and/or cytologically verified leukaemia or lymphoma. At the time of their diagnoses, all the children were aged 0–14 years and were resident in the counties of Greater Manchester or Lancashire. Standardized morbidity ratios were calculated. Poisson regression was used to examine the relationship between incidence rates and small-area (census ward) population density, ethnic composition and deprivation index. There was a monotonic relationship between acute lymphoblastic leukaemia (ALL) incidence and population density (P = 0·05). Higher rates were seen in more densely populated areas. There was evidence for a monotonic relationship between the incidence of the mixed cellularity subtype of Hodgkin's disease (HD) and the Townsend deprivation score (P = 0·001). Markedly higher incidence was associated with greater levels of unemployment and household overcrowding. The results for ALL and mixed cellularity HD support the involvement of environmental factors, such as infections, in disease aetiology.


Publication metadata

Author(s): McNally RJQ; Alston RD; Cairns DP; Eden OB; Birch JM

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2003

Volume: 123

Issue: 1

Pages: 60-65

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1365-2141.2003.04558.x

DOI: 10.1046/j.1365-2141.2003.04558.x

PubMed id: 14510943


Altmetrics

Altmetrics provided by Altmetric


Share