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The tissue-specific RNA-binding protein COLBP is differentially regulated during myogenesis

Lookup NU author(s): Professor Zofia Chrzanowska-LightowlersORCiD, Professor Robert Lightowlers


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Cytochrome c oxidase L-form transcript-binding protein (COLBP) activity parallels the tissue-specific mRNA expression of bovine cytochrome c oxidase liver isopeptides. A similar RNA-binding activity is found in human myoblast and liver Hep G2 cell homogenates. Human COLBP activity, however, is not present in myotubes or adult skeletal muscle. It is proposed that COLBP down-regulation during muscle cell differentiation may underlie oxidase isoform switching during myogenesis.

Publication metadata

Author(s): Preiss T, Chrzanowska-Lightowlers ZM, Lightowlers RN

Publication type: Article

Publication status: Published

Journal: Biochimica et Biophysica Acta

Year: 1994

Volume: 1221

Issue: 3

Pages: 286-289

Print publication date: 28/04/1994

ISSN (print): 0006-3002

ISSN (electronic): 0005-2728

Publisher: Elsevier