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Geographical and ecological analyses of childhood Wilms' tumours and soft tissue sarcomas in North West England: Evidence for environmental aetiological factors

Lookup NU author(s): Dr Richard McNallyORCiD

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Abstract

The aim of this paper was to study the geographical distribution of Wilms’ tumours (WT) and soft-tissue sarcomas (STS) for 0–14 year olds included in a population-based registry from North West England during 1976–2000. Standardised morbidity ratios (SMRs) were calculated. Relationships between incidence rates and small area (ward) population density, ethnic composition, deprivation index and urban–rural status were examined using Poisson regression. There was a non-linear relationship between WT incidence and population density (P=0.008), with a higher incidence associated with wards with low deprivation scores (P=0.02); and which included a greater proportion of whites (P=0.01). For STS, a higher incidence was associated with wards with low deprivation scores (P=0.04); and which were ‘more rural/less urban’ (P=0.03). These results are consistent with a role for localised environmental exposures, in combination with lifestyle factors, in the aetiology of WT. For STS, there is some evidence for the involvement of environmental and/or lifestyle factors.

Publication metadata

Author(s): McNally RJQ; Alston RD; Cairns DP; Eden OB; Kelsey AM; Birch JM

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 2003

Volume: 39

Issue: 11

Pages: 1586-1593

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0959-8049(03)00357-5

DOI: 10.1016/S0959-8049(03)00357-5

PubMed id: 12855266

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