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Lookup NU author(s): Dr Richard McNallyORCiD
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The aim of this paper was to study the geographical distribution of Wilms’ tumours (WT) and soft-tissue sarcomas (STS) for 0–14 year olds included in a population-based registry from North West England during 1976–2000. Standardised morbidity ratios (SMRs) were calculated. Relationships between incidence rates and small area (ward) population density, ethnic composition, deprivation index and urban–rural status were examined using Poisson regression. There was a non-linear relationship between WT incidence and population density (P=0.008), with a higher incidence associated with wards with low deprivation scores (P=0.02); and which included a greater proportion of whites (P=0.01). For STS, a higher incidence was associated with wards with low deprivation scores (P=0.04); and which were ‘more rural/less urban’ (P=0.03). These results are consistent with a role for localised environmental exposures, in combination with lifestyle factors, in the aetiology of WT. For STS, there is some evidence for the involvement of environmental and/or lifestyle factors.
Author(s): McNally RJQ; Alston RD; Cairns DP; Eden OB; Kelsey AM; Birch JM
Publication type: Article
Publication status: Published
Journal: European Journal of Cancer
ISSN (print): 0959-8049
ISSN (electronic): 1879-0852
PubMed id: 12855266
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