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Lookup NU author(s): Dr Richard McNallyORCiD
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The object of this study was to examine cases of Hodgkin's Disease (HD) for evidence of space-time clustering of onsets by age group, sex and disease subtype. Data comprised 2024 cases of HD aged 0–79 years arising throughout the period 1984 to 1993 in the areas covered by a specialist population based register of leukaemias and lymphomas. Knox space-time analysis was used separately for 3 different age groups: childhood (0–14 years), young adult (15–34 years) and older adults (35–79 years); for adult cases separate analysis was carried out by sex and for the nodular and non-nodular sclerosing subtypes. Results showed that space-time clustering of onsets was limited to the nodular sclerosing cases. It was more prominent in young adult nodular sclerosing cases aged 15–34 years (particularly females) diagnosed in the period 1984–88, than in those diagnosed in 1989–93. We conclude that clustering may provide further evidence that an infectious process is involved in the aetiology of young adult nodular sclerosing cases of HD.
Author(s): Gilman EA, McNally RJ, Cartwright RA
Publication type: Article
Publication status: Published
Journal: Leukemia and Lymphoma
ISSN (print): 1042-8194
ISSN (electronic): 1029-2403
Publisher: Informa Healthcare
PubMed id: 10613453
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