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Space-time clustering of Hodgkin's disease in parts of the UK, 1984-1993

Lookup NU author(s): Dr Richard McNallyORCiD


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The object of this study was to examine cases of Hodgkin's Disease (HD) for evidence of space-time clustering of onsets by age group, sex and disease subtype. Data comprised 2024 cases of HD aged 0–79 years arising throughout the period 1984 to 1993 in the areas covered by a specialist population based register of leukaemias and lymphomas. Knox space-time analysis was used separately for 3 different age groups: childhood (0–14 years), young adult (15–34 years) and older adults (35–79 years); for adult cases separate analysis was carried out by sex and for the nodular and non-nodular sclerosing subtypes. Results showed that space-time clustering of onsets was limited to the nodular sclerosing cases. It was more prominent in young adult nodular sclerosing cases aged 15–34 years (particularly females) diagnosed in the period 1984–88, than in those diagnosed in 1989–93. We conclude that clustering may provide further evidence that an infectious process is involved in the aetiology of young adult nodular sclerosing cases of HD.

Publication metadata

Author(s): Gilman EA, McNally RJ, Cartwright RA

Publication type: Article

Publication status: Published

Journal: Leukemia and Lymphoma

Year: 1999

Volume: 36

Issue: 1-2

Pages: 85-100

ISSN (print): 1042-8194

ISSN (electronic): 1029-2403

Publisher: Informa Healthcare


DOI: 10.3109/10428199909145952

PubMed id: 10613453


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