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Rapid onset of chronic granulocytic leukaemia after treatment for Hodgkin's disease

Lookup NU author(s): Professor Graham Jackson, Dr Anne Lennard, Dr Penelope Taylor, Professor Stephen Proctor


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A 17-year-old white female presented with stage IVB Hodgkin's disease. After chemotherapy and radiotherapy she achieved a complete clinical remission and underwent an autologous bone marrow transplant (ABMT). 22 months later she developed chronic granulocytic leukaemia (CGL). Polymerase chain reaction (PCR) analysis of bone marrow harvested at the time of ABMT did not show any evidence of the bcr-abl sequence that was detectable at the diagnosis of CGL. This case provides further information on the kinetics of the development of CGL and adds to the small pool of data on CGL developing after treatment for Hodgkin's disease.

Publication metadata

Author(s): Jackson GH, Latham JA, Lennard AL, Taylor PRA, Proctor SJ

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 1994

Volume: 87

Issue: 1

Pages: 193-195

Print publication date: 01/05/1994

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141


DOI: 10.1111/j.1365-2141.1994.tb04891.x

Notes: 0007-1048 Case Reports Journal Article


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