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Review: Chemical and biological features of Burkholderia cepacia complex lipopolysaccharides

Lookup NU author(s): Professor Anthony De SoyzaORCiD, Professor Antonio Molinaro


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The Burkholderia cepacia complex comprises 10 closely related Gram-negative organisms all of which appear capable of causing disease in humans. These organisms appear of particular relevance to patients with cystic fibrosis. Lipopolysaccharide (LPS) is an important virulence determinant in Gram-negative pathogens. In this review, we highlight important data within the field commenting on LPS/lipid A structure-to-function relationships and cytokine induction capacity of Burkholderia strains studied so far.

Publication metadata

Author(s): De Soyza A, Silipo A, Lanzetta R, Govan JR, Molinaro A

Publication type: Review

Publication status: Published

Journal: Innate Immunity

Year: 2008

Volume: 14

Issue: 3

Pages: 127-144

Print publication date: 01/06/2008

ISSN (print): 1753-4259

ISSN (electronic): 1743-2839


DOI: 10.1177/1753425908093984