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Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades

Lookup NU author(s): Dr Urs Mosimann

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Abstract

The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.

Publication metadata

Author(s): Mosimann UP; Wipfli M; Felblinger J; Hess CW; Schlaepfer TE; Muri RM

Publication type: Article

Publication status: Published

Journal: European Journal of Neuroscience

Year: 2001

Volume: 14

Issue: 3

Pages: 571-575

ISSN (print): 0953-816X

ISSN (electronic): 1460-9568

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.0953-816x.2001.01671.x

DOI: 10.1046/j.0953-816x.2001.01671.x

PubMed id: 11553308

Notes: 0953-816X (Print) Clinical Trial Journal Article

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