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Mismatch repair defects as a cause of resistance to cytotoxic drugs

Lookup NU author(s): Professor Julie Irving, Dr Andrew Hall


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In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.

Publication metadata

Author(s): Irving JAE, Hall AG

Publication type: Review

Publication status: Published

Journal: Expert Review of Anticancer Therapy

Year: 2001

Volume: 1

Issue: 1

Pages: 149-158

Print publication date: 01/01/2001

ISSN (print): 1473-7140

ISSN (electronic): 1744-8328


DOI: 10.1586/14737140.1.1.149

PubMed id: 12113123