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Lookup NU author(s): Professor Julie Irving,
Dr Andrew Hall
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In this short review, we aim to bring together the most recent evidence implicating mismatch repair pathway defects as a cause of drug resistance to a spectrum of chemotherapeutic agents in a variety of cancers. Experimental and clinical studies are discussed and possible strategies that may be employed to overcome the multidrug resistant phenotype afforded by such defects.
Author(s): Irving JAE, Hall AG
Publication type: Review
Publication status: Published
Journal: Expert Review of Anticancer Therapy
Print publication date: 01/01/2001
ISSN (print): 1473-7140
ISSN (electronic): 1744-8328
PubMed id: 12113123