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Is chromatin remodeling required to build sister-chromatid cohesion?

Lookup NU author(s): Dr Stephan Gruber


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Chromosome segregation during mitosis and meiosis depends on the linkage of sister DNA molecules after replication. These links, known as sister-chromatid cohesion, are provided by a multi-subunit complex called cohesin. Recent papers suggest that chromatin-remodeling complexes also have a role in the generation of sister-chromatid cohesion. It remains unclear whether they do so by facilitating the recruitment of cohesin to specific chromosomal sequences or by modifying an event at replication forks giving rise to cohesion between sister DNAs.

Publication metadata

Author(s): Gruber S; Riedel CG; Gregan J; Nasmyth K

Publication type: Article

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 2004

Volume: 29

Issue: 8

Pages: 389-392

ISSN (print): 0968-0004

ISSN (electronic): 0167-7640

Publisher: Elsevier Ltd.


DOI: 10.1016/j.tibs.2004.06.007

Notes: Journal Article Research Support, Non-U.S. Gov't Review England


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