Toggle Main Menu Toggle Search

Open Access padlockePrints

Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers

Lookup NU author(s): Dr Urs Mosimann

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

This study investigated the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) of the left prefrontal cortex (LPFC) on mood in a sham-controlled crossover design. Twenty-five healthy male subjects received HF-rTMS of the LPFC in real and sham conditions. Forty trains (frequency 20 Hz, stimulation intensity 100% of individual motor threshold, train duration 2 s, intertrain interval 28 s) were applied in each session. Mood change from baseline was measured with five visual analog scales (VAS) for sadness, anxiety, happiness, tiredness and pain/discomfort. We were unable to demonstrate significant mood changes from baseline on visual analog scales after either sham or real stimulation of LPFC. There is insufficient evidence to support the general conclusion that HF-rTMS of LPFC has mood effects in healthy volunteers. Future studies should be sham-controlled, have larger sample sizes, and strictly stimulate one single region per session in order to exclude interaction effects with the previous stimulation.


Publication metadata

Author(s): Mosimann UP; Rihs TA; Engeler J; Fisch H; Schlaepfer TE

Publication type: Article

Publication status: Published

Journal: Psychiatry Research

Year: 2000

Volume: 94

Issue: 3

Pages: 251-256

ISSN (print): 0165-1781

ISSN (electronic): 1872-7123

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0165-1781(00)00146-3

DOI: 10.1016/S0165-1781(00)00146-3

Notes: 0165-1781 (Print) Clinical Trial Journal Article


Altmetrics

Altmetrics provided by Altmetric


Share