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Paranoid Psychosis and Myoclonus: Flecainide Toxicity in Renal Failure

Lookup NU author(s): Dr Daniela Lee, Professor Neil SheerinORCiD


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Flecainide is a sodium channel blocker used mainly in the treatment of supraventricular arrhythmias. Central nervous system side effects such as dizziness, visual disturbances, headache and nausea are commonly associated with flecainide, but severe central nervous system toxicity is rare. We report the first case of flecainide toxicity in a patient with end-stage renal failure. Cessation of flecainide therapy resulted in a fall in serum flecainide levels, with associated resolution of adverse central nervous system effects. We also review the pharmacokinetics of flecainide in patients with chronic kidney disease. Copyright (c) 2008 S. Karger AG, Basel.

Publication metadata

Author(s): Ting SM, Lee D, Maclean D, Sheerin NS

Publication type: Article

Publication status: Published

Journal: Cardiology

Year: 2008

Volume: 111

Issue: 2

Pages: 83-86

ISSN (print): 0008-6312

ISSN (electronic): 1421-9751

Publisher: S. Karger AG


DOI: 10.1159/000119694


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