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Nitric oxide synthase gene polymorphisms in Alzheimer's disease and dementia with Lewy bodies

Lookup NU author(s): Professor Ian McKeith, Dr Clive Ballard, Professor Jim Edwardson, Dr Christopher Morris


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Evidence suggests that vascular and inflammatory components may be important in the aetiology of dementia and genetic risk factors affecting these processes may therefore influence disease development. Recently, polymorphisms in the endothelial constitutive nitric oxide synthase 3 (NOS3) and also the inducible nitric oxide synthase gene (NOS2A) have been suggested to lead to increased risk of Alzheimer's disease (AD) or dementia with Lewy bodies. We have studied the relationship of both these NOS gene polymorphisms to development of AD and dementia with Lewy bodies and find no evidence for association with either condition. We conclude that NOS gene polymorphisms do not alter disease risk in the majority of late-onset dementia cases.

Publication metadata

Author(s): McKeith IG; Edwardson JA; Morris CM; Ballard CG; Singleton AB; Gibson AM

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2001

Volume: 303

Issue: 1

Pages: 33-36

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier


DOI: 10.1016/S0304-3940(01)01694-9

PubMed id: 11297817


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