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Spectrum of liver pathology in immune mediated liver diseases

Lookup NU author(s): Professor Alastair BurtORCiD

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Abstract

Immune mechanisms are involved in a wide range of parenchymal liver diseases and are of particular importance in conditions where the pathogenesis appears to be related to loss of tolerance to self antigens. In the liver there are two classical ‘autoimmune’ conditions: primary biliary cirrhosis and autoimmune hepatitis. It is increasingly apparent however that these may represent ends of a spectrum and overlap syndromes are well recognised. Furthermore there is evidence that primary sclerosing cholangitis may be a further example of autoimmune liver disease and overlpa conditions between this and autoimmune hepatitis are described. Histopathological assessment remains an important diagnostic tool in the investigation of autoimmune liver disease, particularly in the context of outlier and overlap conditions.

Publication metadata

Author(s): Burt AD

Publication type: Article

Publication status: Published

Journal: Journal of Gastroenterology and Hepatology

Year: 2004

Volume: 19

Issue: s7

Pages: S353-355

ISSN (print): 0815-9319

ISSN (electronic): 1440-1746

Publisher: Wiley-Blackwell Publishing Asia

URL: http://dx.doi.org/10.1111/j.1440-1746.2004.03647.x

DOI: 10.1111/j.1440-1746.2004.03647.x

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