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Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues

Lookup NU author(s): Dr Gary Litherland


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The rate of glucose transport into cells is of fundamental importance in whole body homeostasis and adaptation to metabolic stresses, and this review examines the signalling mechanisms controlling this process. The events that mediate the action of insulin on glucose transport, which is by far the best characterized paradigm for glucose transport regulation, are discussed. There are several excellent reviews on various aspects of this subject, which are referred to while highlighting very recent developments in the field, including the recently described CAP pathway, and emerging mechanisms for feedback regulation of insulin signalling. The manner in which hormonal signalling is modulated by stimuli such as oxidative and osmotic stress is then discussed. The second major physiological event where glucose transport regulation is critical is the contraction of skeletal muscle, due to the large metabolic demands of this activity. The mechanism of this regulation is distinct from that initiated by insulin, and recent developments will be examined that have begun to clarify how contraction stimulates glucose transport in skeletal muscle, including the roles performed by AMP-activated protein kinase and nitric oxide synthase.

Publication metadata

Author(s): Litherland GJ; Hajduch E; Hundal HS

Publication type: Review

Publication status: Published

Journal: Molecular Membrane Biology

Year: 2001

Volume: 18

Issue: 3

Pages: 195-204

ISSN (print): 0968-7688

ISSN (electronic): 1464-5203


DOI: 10.1080/09687680110076407

Notes: Research Support, Non-U.S. Gov't