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CD4 T-cell epitope mapping

Lookup NU author(s): Professor John Robinson


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The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen- presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules (HLA-A, B, and C in humans and H2-K, D, and L in mice) in the case of CD8+ T cells, or class II molecules (HLA-DR, DP, and DQ in humans and H2-A and E in mice) for CD4+ T cells. However, a significant proportion of T cells recognize peptide antigens bound to nonclassical MHC class Ib molecules such as the human HLA-E (mouse analog Qa1) (4) and mouse H2-M3 (5). In addition, some T cells recognize not peptides but lipid or glycolipid antigens bound to nonclassical MHC class Ib molecules such as CD1 in both humans and mice (6).

Publication metadata

Author(s): Robinson JH; Delvig AA

Editor(s): Pollard, AJ; Maiden, MCJ

Series Editor(s): Walker, J

Publication type: Book Chapter

Publication status: Published

Book Title: Meningococcal Vaccine

Year: 2001

Volume: 66

Pages: 349-360

Series Title: Methods in Molecular Medicine

Publisher: Humana Press

Place Published: Totowa, New Jersey, USA

Library holdings: Search Newcastle University Library for this item

ISBN: 9780896038011