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Lookup NU author(s): Professor John Robinson
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The majority of T cells recognize peptide epitopes bound to major histocompatibility complex (MHC)-encoded glycoproteins on the surface of professional antigen- presenting cells (APC), principally dendritic cells, macrophages, and B cells (1-3). Most T cells are specific for peptide epitopes in association with either classical MHC class Ia molecules (HLA-A, B, and C in humans and H2-K, D, and L in mice) in the case of CD8+ T cells, or class II molecules (HLA-DR, DP, and DQ in humans and H2-A and E in mice) for CD4+ T cells. However, a significant proportion of T cells recognize peptide antigens bound to nonclassical MHC class Ib molecules such as the human HLA-E (mouse analog Qa1) (4) and mouse H2-M3 (5). In addition, some T cells recognize not peptides but lipid or glycolipid antigens bound to nonclassical MHC class Ib molecules such as CD1 in both humans and mice (6).
Author(s): Robinson JH; Delvig AA
Editor(s): Pollard, AJ; Maiden, MCJ
Series Editor(s): Walker, J
Publication type: Book Chapter
Publication status: Published
Book Title: Meningococcal Vaccine
Series Title: Methods in Molecular Medicine
Publisher: Humana Press
Place Published: Totowa, New Jersey, USA
Library holdings: Search Newcastle University Library for this item