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Extracts of ginko biloba and panex ginseng protect brain proteins from the free radical induced oxidative damage in vitro

Lookup NU author(s): Dr Shahid Siddique, Dr David Mantle, Emeritus Professor David Mendelow


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Oxidative damage to normal human brain tissue was induced following exposure to hydroxyl (OH.) or superoxide (O2-.) free radical species generated by CO60 irradiation in vitro. Both enzymic and cytoskeletal proteins showed substantial (dose dependent) oxidative damage following exposure to OH. or O2-., as quantified by SDS-polyacrylamide gel electrophoretic analysis. Extracts of Ginkgo biloba or Panax ginseng showed a remarkable capacity to protect brain tissue proteins from oxidative damage in vitro, even at extreme (2000 kRads) dosage levels of OH. or O2-.. We suggest, therefore, that the beneficial effect of these plant extracts in preventing brain tissue damage in vivo (e.g. following ischemia-reperfusion) may result from their action in protecting brain proteins from oxidative damage, in addition to their previously reported capacity to reduce free radical induced lipid peroxidation.

Publication metadata

Author(s): Mendelow AD; Siddique MS; Mantle D; Eddeb F

Publication type: Article

Publication status: Published

Journal: Acta Neurochirurgica

Year: 2000

Volume: 76

Issue: Suppl.

Pages: 87-90

ISSN (print): 0001-6268

ISSN (electronic): 0942-0940

Publisher: Springer Wien