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Lookup NU author(s): Dr Shahid Siddique,
Dr David Mantle,
Emeritus Professor David Mendelow
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Oxidative damage to normal human brain tissue was induced following exposure to hydroxyl (OH.) or superoxide (O2-.) free radical species generated by CO60 irradiation in vitro. Both enzymic and cytoskeletal proteins showed substantial (dose dependent) oxidative damage following exposure to OH. or O2-., as quantified by SDS-polyacrylamide gel electrophoretic analysis. Extracts of Ginkgo biloba or Panax ginseng showed a remarkable capacity to protect brain tissue proteins from oxidative damage in vitro, even at extreme (2000 kRads) dosage levels of OH. or O2-.. We suggest, therefore, that the beneficial effect of these plant extracts in preventing brain tissue damage in vivo (e.g. following ischemia-reperfusion) may result from their action in protecting brain proteins from oxidative damage, in addition to their previously reported capacity to reduce free radical induced lipid peroxidation.
Author(s): Mendelow AD; Siddique MS; Mantle D; Eddeb F
Publication type: Article
Publication status: Published
Journal: Acta Neurochirurgica
ISSN (print): 0001-6268
ISSN (electronic): 0942-0940
Publisher: Springer Wien