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Lookup NU author(s): Dr Stephen Addinall
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The FtsZ protein is a polymer-forming GTPase which drives bacterial cell division and is structurally and functionally related to eukaryotic tubulins. We have searched for FtsZ-related sequences in all freely accessible databases, then used strict criteria based on the tertiary structure of FtsZ and its well-characterized in vitro and in vivo properties to determine which sequences represent genuine homologues of FtsZ. We have identified 225 full-length FtsZ homologues, which we have used to document, phylum by phylum, the primary sequence characteristics of FtsZ homologues from the Bacteria, Archaea, and Eukaryota. We provide evidence for at least five independent ftsZ gene-duplication events in the bacterial kingdom and suggest the existence of three ancestoral euryarchaeal FtsZ paralogues. In addition, we identify "FtsZ-like" sequences from Bacteria and Archaea that, while showing significant sequence similarity to FtsZs, are unlikely to bind and hydrolyze GTP.
Author(s): Vaughan S, Wickstead B, Gull K, Addinall SG
Publication type: Article
Publication status: Published
Journal: Journal of Molecular Evolution
ISSN (print): 0022-2844
ISSN (electronic): 1432-1432
Publisher: Springer New York LLC
Notes: Research Support, Non-U.S. Gov't
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