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Local therapy and other factors influencing site of relapse in patients with localised Ewing's sarcoma

Lookup NU author(s): Simon Cotterill, Emeritus Professor Alan Craft


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Relapse patterns have been documented in 191 children with localised Ewing's sarcoma treated with the United Kingdom Children's Cancer Group (UKCCSG) Ewing's Tumour regimen ET2. All received chemotherapy comprising ifosfamide, vincristine, doxorubicin and actinomycin D. Local treatment modality was excision and or radiotherapy depending on tumour site and response to primary chemotherapy. Although not strictly comparable, due to the clinical indications used for each modality, local relapse rates were very low and were similar, irrespective of the type of local treatment modality: radiotherapy (3/56), surgery (7/114) or a combination (0/20). Combined relapse (local + distant) rates were similarly low irrespective of the type of local therapy: radiotherapy (4/56), surgery (4/114) or a combination (0/20). Overall survival was lower in females (P = < 0.04), older children (P = < 0.002) and those with primaries at sites other than long bones (P = < 0.02). It is concluded that with effective intensive chemotherapy combined with either radiotherapy or surgery, local control in this study was excellent at sites other than the pelvis. Preventing distant relapse, predominantly to lung and bone, remains the major challenge.

Publication metadata

Author(s): Shankar AG, Pinkerton CR, Atra A, Ashley S, Lewis I, Spooner D, Cannon S, Grimer R, Cotterill SJ, Craft AW

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer

Year: 1999

Volume: 35

Issue: 12

Pages: 1698-1704

Print publication date: 01/11/1999

ISSN (print): 0959-8049

ISSN (electronic): 1879-0852


DOI: 10.1016/S0959-8049(99)00144-6

PubMed id: 10674016

Notes: Group Authors: United Kingdom Children's Cancer Study Group (UKCCSG)


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