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Culture of the marine cyanobacterium, Lyngbya majuscula (Oscillatoriaceae), for bioprocess intensified production of cyclic and linear lipopeptides

Lookup NU author(s): Professor Grant Burgess, Professor Phillip WrightORCiD


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Cyanobacteria are an ancient and diverse group of photosynthetic microorganisms, which inhabit many different and extreme environments. This indicates a high degree of biological adaptation, which has enabled these organisms to thrive and compete effectively in nature. The filamentous cyanobacterium, Lyngbya majuscula, produces several promising antifungal and cytotoxic agents, including laxaphycin A and B and curacin A. Samples of L. majuscula collected from Moorea Island, Tahiti (French Polynesia) and from the Culture Collection of Algae and Protozoa (CCAP 1446/4) were studied and adapted to large scale laboratory culture (5 l). This constitutes a 100-fold scale-up for the culture of this particular strain of L. majuscula. The effect of culture vessel configurations, growth conditions and media compositions on growth of L. majuscula was examined. Using optimised culture conditions, two strains of L. majuscula are currently being evaluated for their production of secondary metabolites. Results will be compared with those obtained from four environmental extracts. Comparisons were made by thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). It was shown that varying the culture conditions under which L. majuscula was grown had the greatest effect on secondary metabolite production, thus providing potential for future bioprocess intensified production.

Publication metadata

Author(s): Burja AM, Abou-Mansour E, Banaigs B, Payri C, Burgess JG, Wright PC

Publication type: Article

Publication status: Published

Journal: Journal of Microbiological Methods

Year: 2002

Volume: 48

Issue: 2-3

Pages: 207-219

Print publication date: 01/02/2002

Online publication date: 27/12/2001

ISSN (print): 0167-7012

ISSN (electronic): 1872-8359

Publisher: Elsevier BV


DOI: 10.1016/S0167-7012(01)00324-4

PubMed id: 11777570


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