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Mechanisms of Joint Destruction and Therapeutic Approaches

Lookup NU author(s): Emeritus Professor Tim Cawston


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Rheumatoid arthritis (RA) is characterized by infiltration of inflammatory cells into the joint. The synovial membrane becomes highly vascularized and the inflammatory cells release cytokines and growth factors. These agents cause the synovial fibroblasts to proliferate, forming pannus tissue, and synovial cells and chondrocytes to release proteolytic enzymes. Destruction of bone and cartilage then proceeds. In osteoarthritis, the chondrocytes are stimulated to produce proteolytic enzymes, leading to focal destruction of cartilage, and in some cases the synovial membrane shows signs of inflammation. As understanding of these diseases has increased, new therapeutic targets have been identified.

Publication metadata

Author(s): Cawston TE

Publication type: Article

Publication status: Published

Journal: Medicine

Year: 2002

Volume: 30

Issue: 8

Pages: 27-31

ISSN (print): 0304-5412

ISSN (electronic): 1578-8822

Publisher: Elsevier Doyma


DOI: 10.1383/medc.


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