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Radicals and oxidative stress in diabetes

Lookup NU author(s): Dr Ian West

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Abstract

Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2 diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins. Mechanisms are considered whereby hyperglycaemia can increase oxidative stress, and change the redox potential of glutathione and whereby reactive oxygen species can cause hyperglycaemia. It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.

Publication metadata

Author(s): West IC

Publication type: Article

Publication status: Published

Journal: Diabetic Medicine

Year: 2000

Volume: 17

Issue: 3

Pages: 171-180

ISSN (print): 0742-3071

ISSN (electronic): 1464-5491

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://onlinelibrary.wiley.com/doi/10.1046/j.1464-5491.2000.00259.x/pdf

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