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Inhibitory effect of Pax4 on the human insulin and islet amyloid polypeptide (IAPP) promoters

Lookup NU author(s): Dr Susan Campbell

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Abstract

Pax4 is a paired-box transcription factor that plays an important role in the development of pancreatic beta-cells. Two Pax4 cDNAs were isolated from a rat insulinoma library. One contained the full-length sequence of Pax4, The other, termed Pax4c, was identical to Pax4 but lacked the sequences encoding 117 amino acids at the COOH-terminus, Pax4 was found to inhibit the human insulin promoter through a sequence element, the C2 box, located at -253 to -244, and the islet amyloid poly peptide promoter through a sequence element located downstream of -138, The inhibitory activity of Pax4 was mapped to separate regions of the protein between amino acids 2-230 and 231-349.

Publication metadata

Author(s): Campbell SC, Cragg H, Elrick LJ, Macfarlane WM, Shennan KIJ, Docherty K

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 1999

Volume: 463

Issue: 1-2

Pages: 53-57

Print publication date: 10/12/1999

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0014-5793(99)01584-7

DOI: 10.1016/S0014-5793(99)01584-7

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