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Regulation of the uterine contractile apparatus and cytoskeleton

Lookup NU author(s): Professor Michael TaggartORCiD


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Parturition at term, the end stage of a successful pregnancy, occurs as a result of powerful, co-ordinated and periodic contractions of uterine smooth muscle (myometrium). To occur in a propitious manner, a high degree of control over the activation of a myometrial cell is required. We review the molecular mechanisms and structural composition of myometrial cells that may contribute to their increased contractile capacity at term. We focus attention on pathways that lead to the activation of filamentous networks traditionally labeled ‘contractile’ or ‘cytoskeletal’ yet draw attention to the fact that functional discrimination between these systems is not absolute.

Publication metadata

Author(s): Taggart MJ, Morgan KG

Publication type: Review

Publication status: Published

Journal: Seminars in Cell Development

Year: 2007

Volume: 18

Issue: 3

Pages: 296-234

ISSN (print): 1084-9521

ISSN (electronic): 1096-3634


DOI: 10.1016/j.semcdb.2007.05.006