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Pharmacokinetically guided dosing of carboplatin and etoposide during peritoneal dialysis and haemodialysis

Lookup NU author(s): Professor Alan Boddy, Professor Herbie Newell, Professor Andrew Pearson


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Two patients with relapsed Wilms' tumour and renal failure requiring dialysis were given carboplatin and etoposide by pharmacokinetically guided dosing. The target area under the drug plasma concentration vs lime curve (AUC) was 6 mg ml-1 min for carboplatin and 18 and 21 mg ml-1 min for etoposide. On course 1 measured AUCs of carboplatin and etoposide were 6 and 20 mg ml-1 min for patient 1 and 6 and 21 mg ml-1 min for patient 2 respectively. Peritoneal dialysis did not remove carboplatin or etoposide from the plasma, however carboplatin but not etoposide was cleared by haemodialysis. Therapy with carboplatin and etoposide is possible in children and adults with renal failure who require dialysis, but in this situation pharmacokinetic monitoring is essential.

Publication metadata

Author(s): English, M., Lowis, S., Peng, B., Boddy, A. V., Newell, D. R., Price, L., Pearson, A. D. J.

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 1996

Volume: 73

Issue: 6

Pages: 776-780

Print publication date: 01/03/1996

ISSN (print): 0007-0920

ISSN (electronic):


PubMed id: 8611379