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Lookup NU author(s): Professor Thomas Lennard
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Women who have palpable breast cysts with intracystic Na/K > 3 may have a lower risk of developing breast cancer than those with intracystic Na/K < 3. In this study significantly higher concentrations of insulin-like growth factor-binding protein-3 (IGFBP-3), insulin-like growth-factors I and II (IGF-I, IGF-II) and transforming growth factor-beta 2 (TGF-β2) were found in the Na/K > 3 sub-group. No difference was found in transforming-growth factor-beta 1 (TGF-β1) levels between the two sub-groups of breast cysts. A positive correlation was obtained for IGFBP-3 and TGF-β1 in the Na/K > 3 sub-group consistent with reports that TGF-β1 may regulate the production of IGFBP-3. Equimolar amounts of total IGFs and IGFBP-3 in breast cyst fluid imply that most, if not all, of these IGFs are protein-bound. The significantly higher concentrations of TGF-β2 in the Na/K > 3 sub-group may partly explain the lower risk of breast cancer in this group of women.
Author(s): Lai L, Erbas H, Meadows K, Lennard TWJ, Holly J
Publication type: Article
Publication status: Published
Journal: Cancer Letters
Year: 1996
Volume: 110
Issue: 1-2
Pages: 207-212
Print publication date: 20/12/1996
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
URL: http://dx.doi.org/10.1016/S0304-3835(96)04497-7
DOI: 10.1016/S0304-3835(96)04497-7
PubMed id: 9018103
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