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Whole body protein metabolism in children with cancer

Lookup NU author(s): Professor Andrew Pearson, Emeritus Professor Alan Craft, Dr Jennifer Kernahan, Professor Kim Bartlett


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Whole body protein synthesis and catabolism were measured using the [ring-2H5]phenylalanine and [l-13C]leucine primed constant infusion technique in 32 paediatric patients with cancer at different stages of treatment. Rates of synthesis (S) and catabolism (C) derived from the [ring-2H5]phenylalanine and [l-13]leucine models were 4.7 (SD 1.3) (S) and 6.0 (1.5) (C) g/d/kg, and 5.5 (0.8) (S) and 6.8 (1.2) (C) g/d/kg, respectively. These results show that these two tracer techniques give similar results in this study population. Comparison of these values with results previously reported for groups of control children using the [ring-2H5]phenylalanine model (S = 3.69 and 3.93; C = 4.09 and 4.28 g/d/kg) and the [l-13C]leucine model (S = 4.32; C = 4.85 g/d/kg) show that rates of synthesis and catabolism were higher in cancer patients than in controls. Thus whole body protein turnover is increased in children under treatment for cancer. Other indices of metabolism such as plasma amino acids and intermediary metabolites were also measured and showed that, although subjects were in isotopic steady state, there were significant metabolic changes during the course of the primed constant infusions used to measure protein turnover.

Publication metadata

Author(s): Daley, S. E., Pearson, A. D. J., Craft, A. W., Kernahan, J., Wyllie, R. A., Price, L., Brock, C., Hetherington, C., Halliday, D., Bartlett, K.

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 1996

Volume: 75

Issue: 4

Pages: 273-281

Print publication date: 01/10/1996

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044


DOI: 10.1136/adc.75.4.273

PubMed id: 8984910


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