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Lookup NU author(s): Professor Richard Boys,
Professor Kevin Glazebrook
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Bergman & Gittins (1985) propose a screen design problem in which a collection of screens for therapeutic activity and toxicity of pharmaceutical compounds is to be sequenced. They describe conditions under which a natural ordering heuristic based on failure probability per unit cost for each screen is optimal. We propose a Bayesian model in which measures of activity and toxicity are given a joint prior density. The above conditions for optimality are satisfied for this model under simply stated conditions. A numerical study suggests that the heuristic performs well more generally.
Author(s): Boys RJ, Glazebrook KD, McCrone CM
Publication type: Article
Publication status: Published
Print publication date: 01/01/1996
ISSN (print): 0006-3444
ISSN (electronic): 1464-3510
Publisher: Oxford University Press
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