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Lookup NU author(s): Emeritus Professor Robert Perry,
Emeritus Professor Elaine Perry,
Dr Margaret Piggott,
Dr Evelyn Jaros,
Professor David Burn
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Neurochemical analyses of post-mortem brain from cases of corticobasal degeneration are extremely rare although nearly 100 cases have been reported in the literature. We detail findings of neurotransmitter derangement in the basal ganglia of a case of neuropathologically confirmed corticobasal degeneration, who presented with dementia. The implications of severe neuronal loss in the substantia nigra and extremely low levels of dopamine and its metabolites in the striatum are considered in relation to the absence of an intrinsic extrapyramidal syndrome.
Author(s): Marshall EF, Perry RH, Perry EK, Piggott MA, Thompson P, Jaros E, Burn DJ
Publication type: Article
Publication status: Published
Journal: Acta Neurologica Scandinavica
Print publication date: 01/01/1997
ISSN (print): 0001-6314
ISSN (electronic): 1600-0404
Publisher: Wiley-Blackwell Publishing, Inc.
PubMed id: 9188904
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