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Lookup NU author(s): Professor Naeem Soomro,
Professor David Neal
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Drugs can cause adverse effects on the urinary tract by a local action, or as a result of systemic effects on the autonomic nervous system, or central nervous control of bladder emptying. Tiaprofenic acid and cyclophosphamide as its metabolite acrolein, for example, can cause haemorrhagic cystitis. Localised retroperitoneal fibrosis, from methysergide, for instance, can lead to hydronephrosis. Agents with anticholinergic actions, such as the tricyclic antidepressants, can result in urinary retention, whilst alpha-adrenoceptor antagonists may lead to stress incontinence in females.
Author(s): Soomro NA, Neal DE
Publication type: Note
Publication status: Published
Journal: Adverse Drug Reaction Bulletin
Print publication date: 01/12/1998
ISSN (print): 0044-6394
ISSN (electronic): 0393-9499