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Adverse drug reactions in the urinary tract

Lookup NU author(s): Professor Naeem Soomro, Professor David Neal


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Drugs can cause adverse effects on the urinary tract by a local action, or as a result of systemic effects on the autonomic nervous system, or central nervous control of bladder emptying. Tiaprofenic acid and cyclophosphamide as its metabolite acrolein, for example, can cause haemorrhagic cystitis. Localised retroperitoneal fibrosis, from methysergide, for instance, can lead to hydronephrosis. Agents with anticholinergic actions, such as the tricyclic antidepressants, can result in urinary retention, whilst alpha-adrenoceptor antagonists may lead to stress incontinence in females.

Publication metadata

Author(s): Soomro NA, Neal DE

Publication type: Note

Publication status: Published

Journal: Adverse Drug Reaction Bulletin

Year: 1998

Volume: 193

Issue: 1

Pages: 735-738

Print publication date: 01/12/1998

ISSN (print): 0044-6394

ISSN (electronic): 0393-9499


DOI: 10.1097/00012995-199812000-00001