Toggle Main Menu Toggle Search

Open Access padlockePrints

Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised

Lookup NU author(s): Professor Julia Newton, Vicki Strugala, Emeritus Professor Oliver James

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Background - It has been proposed that a pathogenic effect of Helicobacter pylori is a weakening of the protective mucus barrier; however, this remains controversial. Aims - To clarify the effects of H pylori infection on the mucus gel barrier in vivo. Methods - Mucus gel polymeric structure and the thickness of the adherent mucus barrier were measured in endoscopic biopsy samples in subjects with and without H pylori infection. Results - There was a significant 18% reduction in the proportion of polymeric gel forming mucin in the adherent mucus layer in H pylori positive compared with negative subjects. There was no change in the adherent mucus thickness between H pylori positive and negative subjects without gastric atrophy (mean (SD): 104 (26) μm, 106 (30) μm respectively). There was however a significant reduction in mucus thickness in those H pylori positive subjects with underlying gastric atrophy (84 (13) μm, p=0.03) compared with those without atrophy. Conclusions - A partial breakdown in gel forming structure of the gastric mucus barrier does occur in H pylori infection per se but this is insufficient to cause a collapse of the mucus barrier.


Publication metadata

Author(s): Newton JL, Jordan N, Oliver L, Strugala V, Pearson J, James OFW, Allen A

Publication type: Article

Publication status: Published

Journal: Gut

Year: 1998

Volume: 43

Issue: 4

Pages: 470-475

Print publication date: 01/01/1998

ISSN (print): 0017-5749

ISSN (electronic): 1468-3288

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/gut.43.4.470

DOI: 10.1136/gut.43.4.470

PubMed id: 9824571


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share