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Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD
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The effects of bupivacaine, a long-acting local anaesthetic, and buprenorphine, an opioid analgesic, administered either pre- or post-operatively, were investigated in a rat laparotomy model. Surgical anaesthesia was induced and maintained with halothane. The type of analgesic treatment was a significant factor in the reduction in body weight and food and water intake which occurred following surgery. The largest reductions were seen in the bupivacaine-treated groups and those animals which received no analgesics. The timing of administration of analgesics had no influence on the effect of bupivacaine administration. The group receiving buprenorphine before surgery showed less depression in food intake than the group receiving buprenorphine at the end of surgery. Animals which received buprenorphine showed less depression of activity than those receiving saline or bupivacaine.
Author(s): Flecknell PA; Hayes JH
Publication type: Article
Publication status: Published
Journal: Laboratory Animals
Print publication date: 01/01/1999
ISSN (print): 0023-6772
ISSN (electronic): 1758-1117
Publisher: Royal Society of Medicine Press Ltd.
PubMed id: 10759387
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