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A comparison of pre- and post-surgical administration of bupivacaine or buprenorphine following laparotomy in the rat

Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD


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The effects of bupivacaine, a long-acting local anaesthetic, and buprenorphine, an opioid analgesic, administered either pre- or post-operatively, were investigated in a rat laparotomy model. Surgical anaesthesia was induced and maintained with halothane. The type of analgesic treatment was a significant factor in the reduction in body weight and food and water intake which occurred following surgery. The largest reductions were seen in the bupivacaine-treated groups and those animals which received no analgesics. The timing of administration of analgesics had no influence on the effect of bupivacaine administration. The group receiving buprenorphine before surgery showed less depression in food intake than the group receiving buprenorphine at the end of surgery. Animals which received buprenorphine showed less depression of activity than those receiving saline or bupivacaine.

Publication metadata

Author(s): Flecknell PA; Hayes JH

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 1999

Volume: 33

Issue: 1

Pages: 16-23

Print publication date: 01/01/1999

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd.


DOI: 10.1258/002367799780578534

PubMed id: 10759387


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