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Osteoarthritic cartilage loses its ability to remain avascular

Lookup NU author(s): Professor Paul Gregg


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Objective: To determine whether human osteoarthritic (OA) cartilage loses its ability to remain avascular when placed into the in-vivo model of angiogenesis, the chick embryo chorio-allantoic membrane (CAM), and to determine specific changes that occur in the cartilage matrix when the cartilage is exposed to an active vasculature. Design: Articular cartilage from OA and non-OA joints was grafted onto the CAM for up to 5 days before fixing and processing for histological, histochemical and immunological examination for specific changes in proteoglycan and collagen. Results: OA cartilage, but not non-OA cartilage, showed invasion of its matrix by blood vessels from the CAM to various extents. Associated with these blood vessels was a loss of staining for proteoglycans and cartilage specific glycosaminoglycans (GAG). A deposition of collagen types I and X was also visualized around the invasive vessels. Conclusions: OA cartilage loses or has already lost its ability to remain avascular when placed onto the chick CAM. Changes occur in the matrix around the invasive blood vessels, specifically a loss of proteoglycan and GAG, and the deposition of new collagen types, notably I and X.

Publication metadata

Author(s): Fenwick SA, Gregg PJ, Rooney P

Publication type: Article

Publication status: Published

Journal: Osteoarthritis and Cartilage

Year: 1999

Volume: 7

Issue: 5

Pages: 441-452

Print publication date: 01/09/1999

ISSN (print): 1063-4584

ISSN (electronic): 1522-9653

Publisher: Elsevier


DOI: 10.1053/joca.1998.0238

PubMed id: 10489316


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