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A trifunctional steroid-based scaffold for combinatorial chemistry

Lookup NU author(s): Dr Mark Elsegood, Professor Richard Jackson

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Abstract

The steroid 3, with three independently-addressable, rigidly-positioned functional groups, has been synthesized in an efficient, multi-gram sequence from inexpensive cholic acid 1. Compound 3 should prove valuable as a starting point for combinatorial libraries with preorganised, co-directed arrays of substituents.

Publication metadata

Author(s): Barry JF, Davis AP, Perez-Payan MN, Elsegood MRJ, Jackson RFW, Gennari C, Piarulli U, Gude M

Publication type: Article

Publication status: Published

Journal: Tetrahedron Letters

Year: 1999

Volume: 40

Issue: 14

Pages: 2849-2852

Print publication date: 02/04/1999

ISSN (print): 0040-4039

ISSN (electronic): 1873-3581

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0040-4039(99)00309-3

DOI: 10.1016/S0040-4039(99)00309-3

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