Browse by author
Lookup NU author(s): Dr Johnny RoughanORCiD, Emeritus Professor Paul FlecknellORCiD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Rats received pentobarbitone (60, 48 and 36 mg/kg i.p.) or ketamine/medetomidine (75/100, 60/80 and 45/60 mg/μg/kg i.p.) alone, or one hour following buprenorphine (0.5 mg/kg s.c.). Animals were anaesthetized once per week for 6 weeks with one of three anaesthetic doses according to a randomized block design. In the pentobarbitone group, animals which received buprenorphine had longer sleep times (236 ± 22 cf. 204 ± 21 min) and longer durations of surgical anaesthesia (83 ± 14 cf. 27 ± 8 min) (P < 0.01), these effects being potentiated with increasing anaesthetic doses (P < 0.01). A greater degree of respiratory depression was found in animals that received buprenorphine (P < 0.01) although this was judged clinically acceptable in all cases. Unexpectedly high mortality and a high incidence of anaesthetic complications (nine of 16 animals) in the ketamine/medetomidine group made statistical analysis of these data impossible. We conclude that for pentobarbitone, pre-anaesthetic administration of buprenorphine reduces the dose of anaesthetic required to produce surgical anaesthesia, in addition to the presumed benefits of pre-emptive analgesia. In view of the high mortality encountered, we advise caution when considering pre-anaesthetic use of opioids in combination with ketamine/medetomidine in rats.
Author(s): Roughan JV, Burzaco Ojeda O, Flecknell PA
Publication type: Article
Publication status: Published
Journal: Laboratory Animals
Year: 1999
Volume: 33
Issue: 3
Pages: 234-242
Print publication date: 01/07/1999
ISSN (print): 0023-6772
ISSN (electronic): 1758-1117
Publisher: Royal Society of Medicine Press Ltd.
URL: http://dx.doi.org/10.1258/002367799780578183
DOI: 10.1258/002367799780578183
PubMed id: 10780842
Altmetrics provided by Altmetric
