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Linear and non-linear analysis of the surface electrocardiogram during human ventricular fibrillation shows evidence of order in the underlying mechanism

Lookup NU author(s): Emeritus Professor Alan MurrayORCiD


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Ventricular fibrillation (VF) is a poorly understood yet potentially lethal cardiac arrhythmia. The electrocardiogram (ECG) time series of VF is investigated by comparison of the linear and non-linear features of VF time series and surrogates in which internal correlations have been destroyed. From 40 ECG time series of human VF and 40 surrogate time series, three quantities are evaluated: the percentage of the linear time-frequency distribution (TFD) exceeding a threshold, the non-linear coarse-grained correlation dimension (D(cg)), and the percentage of diagonal lines in the nonlinear recurrence plot longer than 10 elements (D10). It is found that the mean (SD) percent threshold TFD and D(cg) are higher for the surrogates (6.7% (1.3) and 5.3 (0.6)) than the VF time series (5.6% (0.7) and 3.8(0.9)), whereas the mean D10 is higher for the VF time series (49% (13)) than the surrogates (32% (7)). All of these differences are significant (p < 0.0001) and indicate greater order in the VF time series than in the surrogates. It is therefore shown that both linear and non-linear signal analysis demonstrate order in the ECG time series of VF.

Publication metadata

Author(s): Clayton RH, Murray A

Publication type: Article

Publication status: Published

Journal: Medical and Biological Engineering and Computing

Year: 1999

Volume: 37

Issue: 3

Pages: 354-358

Print publication date: 01/01/1999

ISSN (print): 0140-0118

ISSN (electronic): 1741-0444

Publisher: Springer


DOI: 10.1007/BF02513312

PubMed id: 10505387


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