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The effect of multiple anticonvulsant therapy on the expression of phenytoin-induced gingival overgrowth

Lookup NU author(s): Professor Farhad Kamali, Dr David Ball, Emeritus Professor Robin Seymour


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The potential effect of co-medication with phenobarbitone, primidone and carbamazepine on plasma and saliva concentrations of 5-(4-hydroxyphenyl)-5-phenylhydantoin (4-HPPH), the major metabolite of phenytoin in man and on the incidence of phenytoin-induced gingival overgrowth was investigated in a group of 36 adult epileptic patients. There were no signifiant differences in plasma or saliva concentrations of 4-HPPH or phenytoin in patients prescribed phenytoin alone, compared to those who received phenytoin with either phenobarbitone, primidone, or carbamazepine. In addition, the extent and the incidence of gingival overgrowth were similar in the 2 groups. The results suggest that chronic comedication with other anti-convulsant drugs which induce phenytoin metabolism, does not affect the plasma or saliva 4-HPPB steady-state levels, nor the degree of gingival overgrowth in adult epileptic patients on therapy with phenytoin. © Munksgaard, 1999.

Publication metadata

Author(s): Kamali F, McLaughlin WS, Ball DE, Seymour RA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 1999

Volume: 26

Issue: 12

Pages: 802-805

Print publication date: 01/12/1999

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: Wiley-Blackwell Publishing, Inc.


DOI: 10.1111/j.1600-051X.1999.tb02523.x

PubMed id: 10599907


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