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Lookup NU author(s): Dr Ian Forrest, Emeritus Professor Nick Europe-Finner
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Inhaled epoprostenol (prostacyclin) may be used in the treatment of severe pulmonary hypertension, improving oxygenation and reducing pulmonary artery pressures. We have observed symptomatic benefits of epoprostenol in patients with congenital heart disease that extend beyond acute haemodynamic effects of the drug, which has a short biological half-life. The aim of this study was to examine the effects of epoprostenol in patients and normal subjects on exhaled nitric oxide (eNO), based on the hypothesis that the drug may alter the resting vasoconstrictor/vasodilator balance. Nine patients with pulmonary hypertension complicating left-to-right cardiac shunts and nine healthy controls received 100 μg of nebulized epoprostenol. Exhaled eNO was measured, using a chemiluminescence method, before, immediately after and 18 h after nebulization. There was no significant difference between the two groups in baseline eNO or eNO immediately following nebulized epoprostenol. Epoprostenol produced a delayed elevation in eNO 18 h after nebulization in patients, but not in normal controls. This study supports the concept that epoprostenol, while having no effect on the normal pulmonary circulation, acts on the hypertensive circulation via a mechanism that may result in a delayed alteration of vasoconstrictor/vasodilator balance.
Author(s): Forrest IA, Small T, Corris PA
Publication type: Article
Publication status: Published
Journal: Clinical Science
Year: 1999
Volume: 97
Issue: 1
Pages: 99-102
Print publication date: 01/01/1999
ISSN (print): 0143-5221
ISSN (electronic): 1470-8736
Publisher: Portland Press Ltd.
URL: http://dx.doi.org/10.1042/CS19990006
DOI: 10.1042/CS19990006
PubMed id: 10369800
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