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The influence of the colon on postprandial glucagon-like peptide 1 (7- 36) amide concentration in man

Lookup NU author(s): Professor John MathersORCiD

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Abstract

Glucagon-like peptide (7-36) amide (GLP-1) is an incretin hormone of the enteroinsular axis released rapidly after meals despite the fact that GLP-1 secreting cells (L-cells) occur predominantly in the distal gut. The importance of these colonic L-cells for postprandial GLP-1 was determined in healthy control subjects and in ileostomy patients with minimal small bowel resection (<5 cm). Subjects were fed a high complex carbohydrate test meal (15.3 g starch) followed by two carbohydrate-free, high fat test meals (25 g and 48.7 g fat respectively). Circulating levels of glucose, insulin, glucagon, glucose insulinotrophic peptide (GIP) and GLP-1 were measured over a 9-h postprandial period. For both subject groups the complex carbohydrate test meal failed to elicit a rise in either GIP or GLP-1. However, both hormones were elevated after the fat load although the GLP-1 concentration was significantly reduced in the ileostomist group when compared with controls (P=0.02). Associated with this reduction in circulating GLP-1 was an elevation in glucagon concentration (P=0.012) and a secondary rise in the plasma glucose concentration (P=0.006). These results suggest that the loss of colonic endocrine tissue is an important determinant in the postprandial GLP-1 concentration. Ileostomists should not be assumed to have normal enteroinsular function as the colon appears to have an important role in postprandial metabolism.

Publication metadata

Author(s): Robertson MD, Livesey G, Morgan LM, Hampton SM, Mathers JC

Publication type: Article

Publication status: Published

Journal: Journal of Endocrinology

Year: 1999

Volume: 161

Issue: 1

Pages: 25-31

Print publication date: 01/01/1999

ISSN (print): 0022-0795

ISSN (electronic): 1479-683X

Publisher: BioScientifica Ltd.

URL: http://dx.doi.org/10.1677/joe.0.1610025

DOI: 10.1677/joe.0.1610025

PubMed id: 10194525

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