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An evaluation of buffered ketoprofen in postoperative dental pain

Lookup NU author(s): Emeritus Professor Robin Seymour, John Hawkesford


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The efficacy of single doses of buffered ketoprofen 12.5mg and ibuprofen 200mg was evaluated in a randomized, double-blind, placebo-controlled trial in patients with postoperative pain after third molar surgery. 178 patients (58M) who required the removal of their third molars participated in the study which had received prior ethical approval. Surgery was completed under general anaesthesia and patients were medicated in the early postoperative period. Efficacy parameters assessed during a 6-hour investigation period included time to meaningful pain relief, sum of pain intensity differences (SPIDs) pain relief (SPRID) and total pain relief (TOTPAR). Buffered ketoprofen provided an early onset in time to more meaningful pain relief than either ibuprofen (p=0.023) or placebo (p=0.043). Similarly, SPIDs, SPRIDs and TOTPARs values for ketoprofen were significantly different from ibuprofen (p=0.004) and placebo (p=<0.001). It is concluded that a single dose of buffered ketoprofen 12.5mg is superior to ibuprofen 200mg and placebo in the treatment of post-operative pain after third molar surgery.

Publication metadata

Author(s): Seymour RA, Hawkesford JE

Publication type: Article

Publication status: Published

Journal: Clinical Pharmacology and Therapeutics

Year: 1999

Volume: 65

Issue: 2

Pages: 120

Print publication date: 01/01/1999

ISSN (print): 0009-9236

ISSN (electronic): 1532-6535

Publisher: Nature Publishing Group


DOI: 10.1016/S0009-9236(99)80013-7


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