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Lookup NU author(s): Emeritus Professor Robin Seymour,
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The efficacy of single doses of buffered ketoprofen 12.5mg and ibuprofen 200mg was evaluated in a randomized, double-blind, placebo-controlled trial in patients with postoperative pain after third molar surgery. 178 patients (58M) who required the removal of their third molars participated in the study which had received prior ethical approval. Surgery was completed under general anaesthesia and patients were medicated in the early postoperative period. Efficacy parameters assessed during a 6-hour investigation period included time to meaningful pain relief, sum of pain intensity differences (SPIDs) pain relief (SPRID) and total pain relief (TOTPAR). Buffered ketoprofen provided an early onset in time to more meaningful pain relief than either ibuprofen (p=0.023) or placebo (p=0.043). Similarly, SPIDs, SPRIDs and TOTPARs values for ketoprofen were significantly different from ibuprofen (p=0.004) and placebo (p=<0.001). It is concluded that a single dose of buffered ketoprofen 12.5mg is superior to ibuprofen 200mg and placebo in the treatment of post-operative pain after third molar surgery.
Author(s): Seymour RA, Hawkesford JE
Publication type: Article
Publication status: Published
Journal: Clinical Pharmacology and Therapeutics
Print publication date: 01/01/1999
ISSN (print): 0009-9236
ISSN (electronic): 1532-6535
Publisher: Nature Publishing Group
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