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Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats - A clinical trial

Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD, Dr Johnny RoughanORCiD, Robert Stewart


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Buprenorphine (0.1, 0.2, 0.3 or 0.4 mg/kg) in a flavoured gelatin base was administered preoperatively to rats undergoing a flank laparotomy. A control group of animals underwent surgery and received only flavoured gelatin. Body weight loss was significantly greater in the group which received no analgesia than in any of the analgesic-treated groups (P < 0.01). Food consumption was reduced significantly in all groups except in those animals which received 0.3 mg/kg buprenorphine. Water consumption was significantly reduced in the control (no analgesia) group (P < 0.001), but was not significantly depressed in the analgesic-treated groups (P > 0.05). Between-group comparisons did not show any significant difference between the different dose rates of analgesia used on either the change in body weight or the reduction in food or water consumption. The results of this study support the use of buprenorphine jelly for post-surgical analgesia in rats. This route of delivery is easy to use, and causes a minimum of stress to the rats.

Publication metadata

Author(s): Flecknell PA, Roughan JV, Stewart R

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 1999

Volume: 33

Issue: 2

Pages: 169-174

Print publication date: 01/04/1999

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press Ltd.


DOI: 10.1258/002367799780578381

PubMed id: 10780821


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