ePrints

Induction of anaesthesia with sevoflurane and isoflurane in the rabbit

Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD, Dr Johnny RoughanORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The effects of induction of anaesthesia with sevoflurane and isoflurane were studied in rabbits. All rabbits had periods of apnoea (ranging from 30-180 s) during induction which resulted in moderate hypercapnia and acidosis. Arterial pCO2 rose from 4.1 ± 0.3 kPa to a peak of 7.6 ± 0.4 KPa (mean ± SD) (both agents). All animals showed a significant reduction in heart rate (P < 0.05). Heart rate (HR) fell from 226 ± 33 to a minimum during induction of 57 ± 32 (sevoflurane) and 199 ± 41 to 45 ± 11 (isoflurane). Most animals struggled violently during induction. Use of sevoflurane did not prevent the breath-holding response seen during induction of anaesthesia with other volatile anaesthetics in this species, and the severe apnoea which occurs may represent a significant hazard. The behaviour of the animals indicated that both sevoflurane and isoflurane are aversive, suggesting that this technique should be avoided whenever possible.

Publication metadata

Author(s): Flecknell PA, Roughan JV, Hedenqvist P

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 1999

Volume: 33

Issue: 1

Pages: 41-46

Print publication date: 01/01/1999

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press

URL: http://dx.doi.org/10.1258/002367799780578516

DOI: 10.1258/002367799780578516

PubMed id: 10759391

Altmetrics

Share