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Induction of anaesthesia with sevoflurane and isoflurane in the rabbit

Lookup NU author(s): Emeritus Professor Paul FlecknellORCiD, Dr Johnny RoughanORCiD


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The effects of induction of anaesthesia with sevoflurane and isoflurane were studied in rabbits. All rabbits had periods of apnoea (ranging from 30-180 s) during induction which resulted in moderate hypercapnia and acidosis. Arterial pCO2 rose from 4.1 ± 0.3 kPa to a peak of 7.6 ± 0.4 KPa (mean ± SD) (both agents). All animals showed a significant reduction in heart rate (P < 0.05). Heart rate (HR) fell from 226 ± 33 to a minimum during induction of 57 ± 32 (sevoflurane) and 199 ± 41 to 45 ± 11 (isoflurane). Most animals struggled violently during induction. Use of sevoflurane did not prevent the breath-holding response seen during induction of anaesthesia with other volatile anaesthetics in this species, and the severe apnoea which occurs may represent a significant hazard. The behaviour of the animals indicated that both sevoflurane and isoflurane are aversive, suggesting that this technique should be avoided whenever possible.

Publication metadata

Author(s): Flecknell PA, Roughan JV, Hedenqvist P

Publication type: Article

Publication status: Published

Journal: Laboratory Animals

Year: 1999

Volume: 33

Issue: 1

Pages: 41-46

Print publication date: 01/01/1999

ISSN (print): 0023-6772

ISSN (electronic): 1758-1117

Publisher: Royal Society of Medicine Press


DOI: 10.1258/002367799780578516

PubMed id: 10759391


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