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Lookup NU author(s): Satya Varanasi,
Dr Surinder Papiha,
Dr Harish Datta
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Aim - To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone. Methods - HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours. Results - Five of the eight patients were found to be positive for HLA-DRB1*0801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1*080 also expressed DRB1*070. Conclusions - HLA-DRB1*080 is predominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.
Author(s): Varanasi SS, Athanasou NA, Briceno I, Papiha SS, Datta HK
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Pathology
Print publication date: 01/10/1999
ISSN (print): 0021-9746
Publisher: B M J Group
PubMed id: 10674041
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