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In-vivo demonstration of dopaminergic degeneration in dementia with Lewy bodies

Lookup NU author(s): Professor Ian McKeith


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With the dopaminergic presynaptic ligand FP-CIT and single photon emission tomography we have shown a severe dopaminergic degeneration in a patient with a necropsy confirmed diagnosis of dementia with Lewy bodies (DLB). We suggest that functional imaging of the nigrostriatal dopamine pathway helps to distinguish DLB from Alzheimer's disease during life.

Publication metadata

Author(s): Walker Z, Costa DC, Ince P, McKeith IG, Katona CLE

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 1999

Volume: 354

Issue: 9179

Pages: 646-647

Print publication date: 21/08/1999

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group


DOI: 10.1016/S0140-6736(99)01178-2

PubMed id: 10466669


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