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The kidney and the pathogenesis of pre-eclampsia

Lookup NU author(s): Emeritus Professor John Davison


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This review emphasizes that whatever the pathogenesis of pre-eclampsia, the ultimate target is the maternal vascular endothelium which is in abundance within the kidneys. Glomerular capillary endotheliosis is accompanied by decreased renal haemodynamics, disordered renal vascular sensitivity, hypofiltration and loss of permselectivity with non-selective proteinura. Altered tubular function contributes to sodium retention and hypercuricaemia. Occasionally, functional impairment is very severe with both tubular and cortical necrosis. The renal changes of pre-eclampsia are usually fully reversible.

Publication metadata

Author(s): Moran P, Davison JM

Publication type: Review

Publication status: Published

Journal: Current Obstetrics and Gynaecology

Year: 1999

Volume: 9

Issue: 4

Pages: 196-202

Print publication date: 01/12/1999

ISSN (print): 0957-5847

ISSN (electronic):


DOI: 10.1054/cuog.1999.0039