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Mood, neuropsychological function and cognitions in premenstrual dysphoric disorder

Lookup NU author(s): Dr Iain Macmillan, Professor Allan Young



Background. Neuropsychological function and cognitive correlates of depression have not previously been examined in a rigorously defined population of patients suffering from premenstrual dysphoric disorder (PMDD). Method. Mood, neuropsychological function and cognition were measured in 10 PMDD patients and 10 age-matched controls in both phases of the menstrual cycle in a random order, counterbalanced design. Results. The BDI was significantly elevated in the luteal phase of PMDD patients only while other cognitive measures showed no significant differences. Working memory was impaired in the luteal phase of the menstrual cycle with no significant differences between PMDD and control subjects. Conclusion. Despite the small sample size, these results show that the BDI is sensitive to the mood fluctuations of PMDD patients. An impairment in working memory was also found although this is a general menstrual cycle effect.

Publication metadata

Author(s): Man MS, MacMillan I, Scott J, Young AH

Publication type: Article

Publication status: Published

Journal: Psychological Medicine

Year: 1999

Volume: 29

Issue: 3

Pages: 727-733

Print publication date: 01/01/1999

Date deposited: 07/05/2014

ISSN (print): 0033-2917

ISSN (electronic): 1469-8978

Publisher: Cambridge University Press


DOI: 10.1017/S0033291798007715

PubMed id: 10405094


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