Browse by author
Lookup NU author(s): Gavin Cuthbert,
Dr Nicholas Bown
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
We report a case of acute myeloid leukemia (AML) M5a showing a jumping translocation with a breakpoint at 11q23. Fluorescence in situ hybridization (FISH) demonstrated triplication of the MLL gene and the presence of interstitial telomeric sequences, supporting the role of repetitive sequences in the mechanism of jumping translocations. Southern blot analysis of the MLL breakpoint cluster region showed the presence of an MLL gene rearrangement. Jumping translocation with MLL gene rearrangement is a previously unreported phenomenon in leukemia cytogenetics.
Author(s): Cuthbert G, McCullough S, Finney R, Breese G, Bown N
Publication type: Article
Publication status: Published
Journal: Genes, Chromosomes and Cancer
Print publication date: 01/04/1999
ISSN (print): 1045-2257
ISSN (electronic): 1098-2264
Publisher: John Wiley & Sons, Inc.
PubMed id: 10092126
Altmetrics provided by Altmetric