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Bactericidal activity and cytotoxicity of antibacterial monomer MDPB

Lookup NU author(s): Emeritus Professor Roy Russell


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The aim of this study was to investigate bactericidal characteristics and cytotoxicity of the newly developed antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB). To evaluate the bactericidal activity of MDPB against oral streptococci, the minimum bactericidal concentration (MBC) for seven species and time-kill kinetics against Streptococcus mutans were determined. The cytotoxic effects of MDPB on human pulpal cells were assessed by [3H]-thymidine uptake after contact with MDPB solutions at various concentrations. MDPB showed strong bactericidal activity against seven streptococci, the MBC value ranging from 31.1 to 62.5 μg ml-1. Time-kill determination indicated a rapid killing effect of MDPB at 250 μg ml-1 or over, and all cells were killed within 1 min by MDPB at 500 μg ml-1 or over. No cytotoxic effect was observed on contact with MDPB at concentrations of 10 μg ml-1 or less, and the toxicity of MDPB was considered to be similar to those of other monomers used for dental materials. These results suggest that MDPB can be effectively incorporated in dental resin-based materials to provide bactericidal activity against oral bacteria.

Publication metadata

Author(s): Russell RRB; Imazato S; Ebi N; Tarumi H; Kaneko T; Ebisu S

Publication type: Article

Publication status: Published

Journal: Biomaterials

Year: 1999

Volume: 20

Issue: 9

Pages: 899-903

Print publication date: 01/05/1999

ISSN (print): 0142-9612

ISSN (electronic): 1878-5905

Publisher: Elsevier BV


DOI: 10.1016/S0142-9612(98)00247-6

PubMed id: 10226716


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