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Effect of flavonoids on protease activities in human skeletal muscle tissue in vitro

Lookup NU author(s): Dr David Mantle, Gavin Falkous, Emeritus Professor Elaine Perry

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Abstract

The effect of a representative range of flavonoid compounds on the activities of a range of proteolytic enzyme types in human skeletal muscle tissue was determined in vitro. All of the proteases showed some degree of inhibition by all of the flavonoid compounds investigated, with IC50 values (concentration of flavonoid required to inhibit initial activity of muscle proteases by 50%) for various enzyme/flavonoid combinations ranging from approx. 50 μmol/l to 2 mmol/l. These data demonstrate that in addition to their well described antioxidant characteristics, flavonoids also possess novel antiproteolytic inhibitory activity in vitro, which may in part explain some of the beneficial effects of these plant derived compounds in vivo. Copyright (C) 1999 Elsevier Science B.V.

Publication metadata

Author(s): Mantle D, Falkous G, Perry EK

Publication type: Article

Publication status: Published

Journal: Clinica Chimica Acta

Year: 1999

Volume: 285

Issue: 1-2

Pages: 13-20

Print publication date: 01/07/1999

ISSN (print): 0009-8981

ISSN (electronic): 1873-3492

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/S0009-8981(99)00050-9

DOI: 10.1016/S0009-8981(99)00050-9

PubMed id: 10481919

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