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Lookup NU author(s): Dr David Mantle,
Emeritus Professor Elaine Perry
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The effect of a representative range of flavonoid compounds on the activities of a range of proteolytic enzyme types in human skeletal muscle tissue was determined in vitro. All of the proteases showed some degree of inhibition by all of the flavonoid compounds investigated, with IC50 values (concentration of flavonoid required to inhibit initial activity of muscle proteases by 50%) for various enzyme/flavonoid combinations ranging from approx. 50 μmol/l to 2 mmol/l. These data demonstrate that in addition to their well described antioxidant characteristics, flavonoids also possess novel antiproteolytic inhibitory activity in vitro, which may in part explain some of the beneficial effects of these plant derived compounds in vivo. Copyright (C) 1999 Elsevier Science B.V.
Author(s): Mantle D, Falkous G, Perry EK
Publication type: Article
Publication status: Published
Journal: Clinica Chimica Acta
Print publication date: 01/07/1999
ISSN (print): 0009-8981
ISSN (electronic): 1873-3492
PubMed id: 10481919
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