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Lookup NU author(s): Dr Vincent Monchois, Professor Jeremy LakeyORCiD, Emeritus Professor Roy Russell
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Multiple sequence alignment and structure prediction of glucansucrases produced by oral streptococci and Leuconostoc mesenteroides showed that all have common structural features, with three major domains. There is no conservation of primary sequence or structure in the N-terminal variable region. Sequence-based structure prediction combined with circular dichroism spectrum analysis of purified truncated forms of Streptococcus downei GTF-I revealed that the core catalytic region has a defined structure consistent with the proposed (α/β)8-barrel structure. The C-terminal domain is a mixed structure with significant amounts of β-sheet and random-coil. This information contributes to the development of our understanding of structure-function relationships in glucansucrases. Copyright (C) 1999 Federation of European Microbiological Societies.
Author(s): Monchois V, Lakey JH, Russell RRB
Publication type: Article
Publication status: Published
Journal: FEMS Microbiology Letters
Year: 1999
Volume: 177
Issue: 2
Pages: 243-248
Print publication date: 15/08/1999
ISSN (print): 0378-1097
ISSN (electronic): 1574-6968
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1016/S0378-1097(99)00317-1
DOI: 10.1016/S0378-1097(99)00317-1
PubMed id: 10474191
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